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KMID : 0981820070270040248
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Korean Journal of Laboratory Medicine
2007 Volume.27 No. 4 p.248 ~ p.252
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A Case of IgA kappa Light Chain Deposition Disease and Combined Adult Fanconi Syndrome with Auer rod-like Intracytoplasmic Inclusions in Plasma Cells and Proximal Renal Tubular Cells
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Kahng Ji-Min
Shin Seok-Joon
Han Kyoung-Ja
Kim Jean-A
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Abstract
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We report a case of IgA kappa light chain deposition disease and combined adult Fanconi syndrome with Auer rod-like intracytoplasmic inclusions in plasma cells and proximal renal tubular cells in a 54-yr-old female. Cytochemical stainings revealed a strong acid phosphatase activity of the inclusions and weak periodic acid-Schiff positivity, whereas the reactions for peroxidase and -naphthyl acetate esterase were negative. An immunostaining verified IgA-kappa inside the plasma cells. Kidney biopsy revealed Bence Jones cast nephropathy with kappa light chain positivity, and Congo red staining was negative. Electron microscopy showed needle-shaped crystals located in tubular epithelial cells. (Korean J Lab Med 2007;27:248-52)
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KEYWORD
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Auer rod-like inclusion, Light chain deposition disease, Fanconi syndrome
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